Model Repository


1. Example model files

Model Repository

A collection of XPPAUT .ode model files is provided in the folder ode model.
These models are taken from the following works:
1. Li, C., & Wang, J. (2015). Quantifying the landscape for development and cancer from a core cancer stem cell circuit. Cancer research, 75(13),
  2607-2618.
2. Wang, J., Zhang, K., Xu, L., & Wang, E. (2011). Quantifying the Waddington landscape and biological paths for development and differentiation.
  Proceedings of the National Academy of Sciences, 108(20), 8257-8262.
3. Huang, S., Guo, Y. P., May, G., & Enver, T. (2007). Bifurcation dynamics in lineage-commitment in bipotent progenitor cells. Developmental
  biology, 305(2), 695-713.
4. Gardner, T. S., Cantor, C. R., & Collins, J. J. (2000). Construction of a genetic toggle switch in Escherichia coli. Nature, 403(6767), 339.
5. Zhou, J. X., Aliyu, M. D. S., Aurell, E., & Huang, S. (2012). Quasi-potential landscape in complex multi-stable systems. Journal of the Royal
  Society Interface, 9(77), 3539-3553.

Two SBML model files are provided in the folder SBML model
These models are taken from the following works:
1. Gardner, T. S., Cantor, C. R., & Collins, J. J. (2000). Construction of a genetic toggle switch in Escherichia coli. Nature, 403(6767), 339.
2. Li, C., & Wang, J. (2015). Quantifying the landscape for development and cancer from a core cancer stem cell circuit. Cancer research, 75(13),
  2607-2618.

The SBML model files were created using SBML Editor from this paper by Rodriguez et al. (2007).
Rodriguez, N., Donizelli, M., & Le Novère, N. (2007). SBMLeditor: effective creation of models in the Systems Biology Markup Language (SBML). BMC bioinformatics, 8(1), 79.



Users can save their model in ode file and simulated Waddington’s epigenetic landscape in MCLand file format (Python pickle .pckl). MCLand also supports SBML model file.


If you have any questions, suggestions or feedback, please email to:zhengjie@shanghaitech.edu.cn


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